NutriStack
Cat's Claw and Turmeric/Curcumin, a synergy.
Combined use broadens anti-inflammatory coverage by suppressing NF-kB driven cytokine production through complementary pathways, supporting joint comfort.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Cat's Claw and Turmeric/Curcumin
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Combined use broadens anti-inflammatory coverage by suppressing NF-kB driven cytokine production through complementary pathways, supporting joint comfort.
Mechanism. Cat's Claw pentacyclic oxindole alkaloids and curcuminoids both inhibit NF-kB activation and downstream TNF-alpha and prostaglandin synthesis, producing additive cytokine suppression.
Recommendation. Reasonable to stack for joint or inflammatory support. Take with food and monitor for any added GI upset.
Sources (2)
- Sandoval M et al., Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content, Phytomedicine, 2002
- Aggarwal BB, Harikumar KB, Potential therapeutic effects of curcumin against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases, International Journal of Biochemistry and Cell Biology, 2009
Stack Score
How this pair moves the number.
Effect on the composite score
If both Cat's Claw and Turmeric/Curcumin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.