NutriStack
Clindamycin and Lactobacillus Rhamnosus, a synergy.
Lactobacillus rhamnosus GG reduces antibiotic-associated diarrhea during clindamycin therapy, which carries one of the highest baseline rates of AAD and C. difficile infection. Separation from antibiotic dosing preserves bacterial viability.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
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At a glance
- Substances
- Clindamycin and Lactobacillus Rhamnosus
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Lactobacillus rhamnosus GG reduces antibiotic-associated diarrhea during clindamycin therapy, which carries one of the highest baseline rates of AAD and C. difficile infection. Separation from antibiotic dosing preserves bacterial viability.
Mechanism. L. rhamnosus restores colonization resistance and competes with opportunistic pathogens; it also produces antimicrobial peptides and short-chain fatty acids that suppress C. difficile overgrowth.
Recommendation. Strongly consider Lactobacillus rhamnosus throughout your clindamycin course, separated by at least 2 hours from each antibiotic dose. Continue for at least 2 weeks after the antibiotic ends.
Minimum separation. 120
Sources (2)
- Barnes D, Yeh AM. Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children. Nutr Clin Pract. 2015;30(6):747-59. PMID 26538058
- Doar NW, Samuthiram SD. Qualitative Analysis of the Efficacy of Probiotic Strains in the Prevention of Antibiotic-Associated Diarrhea. Cureus. 2023;15(6):e40261. PMID 37440799
Stack Score
How this pair moves the number.
Effect on the composite score
If both Clindamycin and Lactobacillus Rhamnosus are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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