NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Clindamycin and Probiotics: what the published research says

PubMed indexes 8 records that name Clindamycin and Probiotics together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Clindamycin and Probiotics. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Clindamycin and Probiotics.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Therapeutic effects of probiotics on neurotoxicity induced by clindamycin and propionic acid in juvenile hamsters.

Metabolic brain disease · 2018 · PMID 30019266

Animal study

“These findings suggest that bacteria overgrowth caused by PPA and clindamycin was efficient to illustrate signs of neuronal toxicity. The present study indicates that probiotic treatment can improve poor detoxification, oxidative stress, and altered gut microbiota as mechanisms implicated in the etiology of many neurological disorders.”

Al-Orf et al. · From the abstract

Names both Clindamycin and Probiotics in its title.

A Gene Homologous to rRNA Methylase Genes Confers Erythromycin and Clindamycin Resistance in Bifidobacterium breve.

Applied and environmental microbiology · 2018 · PMID 29500262

Human subjects

“This gene seems to be very uncommon in other bifidobacteria and in the gut microbiomes of both adults and infants. Even though conjugation experiments showed the absence of transferability under in vitro conditions, it has been predicted to be located in a putative genomic island recently acquired by specific bifidobacterial strains.”

MartĂ­nez et al. · From the abstract

Names both Clindamycin and Probiotics in its title.

The inhibitory effect of clindamycin on Lactobacillus in vitro.

Infectious diseases in obstetrics and gynecology · 2001 · PMID 11916182

Human subjects

“High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus.”

Aroutcheva et al. · Authors' conclusion

Names both Clindamycin and Probiotics in its title.

Effects of bacterial vaginosis treatment during pregnancy on maternal-fetal outcome: A systematic review and network meta-analysis.

European journal of obstetrics, gynecology, and reproductive biology · 2025 · PMID 39946993

Network Meta-AnalysisSystematic ReviewHuman subjects

“The current evidence fails to endorse the treatment of BV during pregnancy as a means to mitigate the risk of preterm delivery. Although probiotic therapies exhibit promising potential, the available data remains inadequate. Future research is necessary to further establish the safety and effectiveness of antibiotics and probiotics in the prevention or management of BV during pregnancy.”

Wu et al. · Authors' conclusion

Names Clindamycin and Probiotics together in an interaction, co-administration, or pharmacokinetic context.

Lactobacillus acidophilus, Bifidobacterium lactis and Lactobacillus F19 prevent antibiotic-associated ecological disturbances of Bacteroides fragilis in the intestine.

The Journal of antimicrobial chemotherapy · 2003 · PMID 12865387

Clinical TrialComparative StudyRandomized Controlled Trial

“The probiotic microorganisms evaluated in this study prevented ecological disturbances in the numbers of intestinal Bacteroides fragilis group species during clindamycin administration.”

Sullivan et al. · Authors' conclusion

Names Clindamycin and Probiotics together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Clindamycin, Probiotics, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.