What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Clindamycin + Saccharomyces Boulardii pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Clindamycin and Saccharomyces Boulardii, a synergy.

Q: Can I take Clindamycin and Saccharomyces Boulardii together?

Yes. The combination of Clindamycin and Saccharomyces Boulardii produces a measurable benefit. Clindamycin carries one of the highest risks of C. difficile-associated colitis among commonly used antibiotics. Saccharomyces boulardii has strong evidence for reducing antibiotic-associated diarrhea and C. difficile infection during high-risk antibiotic exposure. Because it is a yeast, it is unaffected by clindamycin.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Clindamycin carries one of the highest risks of C. difficile-associated colitis among commonly used antibiotics. Saccharomyces boulardii has strong evidence for reducing antibiotic-associated diarrhea and C. difficile infection during high-risk antibiotic exposure. Because it is a yeast, it is unaffected by clindamycin.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Clindamycin and Saccharomyces Boulardii
Pair type: Synergy
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Strong evidence

Synergy

What is happening. Clindamycin carries one of the highest risks of C. difficile-associated colitis among commonly used antibiotics. Saccharomyces boulardii has strong evidence for reducing antibiotic-associated diarrhea and C. difficile infection during high-risk antibiotic exposure. Because it is a yeast, it is unaffected by clindamycin.

Mechanism. S. boulardii produces proteases that degrade C. difficile toxins A and B, stimulates secretory IgA, and competes with C. difficile for binding sites on colonic epithelium. As a yeast, it is intrinsically resistant to antibacterial drugs.

Recommendation. Strongly consider taking Saccharomyces boulardii throughout your clindamycin course. Timing flexibility is greater than with bacterial probiotics. Continue for at least 2 weeks after the antibiotic ends.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Clindamycin and Saccharomyces Boulardii are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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