NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Metronidazole and Saccharomyces Boulardii: what the published research says

PubMed indexes 5 records that name Metronidazole and Saccharomyces Boulardii together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Metronidazole and Saccharomyces Boulardii. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

5 studies naming Metronidazole and Saccharomyces Boulardii.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Clinical efficacy of Saccharomyces boulardii and metronidazole compared to metronidazole alone in children with acute bloody diarrhea caused by amebiasis: a prospective, randomized, open label study.

The American journal of tropical medicine and hygiene · 2009 · PMID 19478257

Randomized Controlled Trial50 participants

“On day 10, all children were cured and cysts had disappeared in all. The addition of Sb to metronidazole in amebiasis significantly decreases duration of (bloody) diarrhea and enhances clearance of cysts.”

Dinleyici et al. · From the abstract

Names both Metronidazole and Saccharomyces Boulardii in its title.

Probiotics for treatment of Clostridium difficile-associated colitis in adults.

The Cochrane database of systematic reviews · 2008 · PMID 18254055

Systematic ReviewHuman subjects

“There is insufficient evidence to recommend probiotic therapy as an adjunct to antibiotic therapy for C. difficile colitis. There is no evidence to support the use of probiotics alone in the treatment of C. difficile colitis.”

Pillai et al. · Authors' conclusion

Names Metronidazole and Saccharomyces Boulardii together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Metronidazole, Saccharomyces Boulardii, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.