NutriStack
Clopidogrel and Ginger Extract, a caution.
Ginger extract inhibits cyclooxygenase and reduces platelet thromboxane A2 generation. Added to clopidogrel's P2Y12 inhibition, ginger supplements stack antiplatelet activity and can increase bleeding risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
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At a glance
- Substances
- Clopidogrel and Ginger Extract
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Ginger extract inhibits cyclooxygenase and reduces platelet thromboxane A2 generation. Added to clopidogrel's P2Y12 inhibition, ginger supplements stack antiplatelet activity and can increase bleeding risk.
Mechanism. Gingerols and shogaols inhibit COX and reduce platelet thromboxane A2. This adds to clopidogrel's blockade of ADP-mediated platelet activation via P2Y12.
Recommendation. Avoid concentrated ginger extract on clopidogrel. Culinary amounts of ginger in food are fine. Stop ginger supplements at least 7 days before any planned surgery.
Sources (2)
- Marx W, McKavanagh D, McCarthy AL, et al. The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review. PLoS One. 2015;10(10):e0141119. PMID 26488162
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57(13):1221-7. PMID 10902065
Stack Score
How this pair moves the number.
Effect on the composite score
If both Clopidogrel and Ginger Extract are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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