NutriStack
Copper and Molybdenum, a caution.
High molybdenum intake can reduce copper bioavailability and accelerate copper depletion, potentially worsening or precipitating copper deficiency over time.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Copper and Molybdenum
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. High molybdenum intake can reduce copper bioavailability and accelerate copper depletion, potentially worsening or precipitating copper deficiency over time.
Mechanism. Excess molybdenum, particularly with dietary sulfur, promotes formation of thiomolybdate compounds that bind copper and increase its biliary and urinary excretion, lowering systemic copper.
Recommendation. Avoid chronic high-dose molybdenum supplementation alongside copper-restricted diets. If both are needed, monitor copper status (ceruloplasmin) under clinician guidance and keep molybdenum at nutritional doses.
Sources (2)
- Turnlund JR, Keyes WR. Dietary molybdenum: effect on copper absorption, excretion, and status in young men. Trace Elements in Man and Animals, 2000
- Vyskocil A, Viau C. Assessment of molybdenum toxicity in humans. J Appl Toxicol. 1999. PMID 10362269
Stack Score
How this pair moves the number.
Effect on the composite score
If both Copper and Molybdenum are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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