Supplement × Supplement·a caution·Insufficient evidence
Both can increase scale weight or water retention signals; MK-677 edema can be clinically important.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Both can increase scale weight or water retention signals; MK-677 edema can be clinically important.
Mechanism. Creatine water retention plus GH/IGF-1-related fluid retention.
Recommendation. Watch for ankle swelling, numbness, blood pressure changes, and shortness of breath, not just weight gain.
Effect on the composite score
If both Creatine and MK-677 (Ibutamoren) are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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