Supplement × Supplement·a caution·Emerging evidence
Berberine may lower glucose while MK-677 can worsen insulin resistance and increase appetite.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Berberine may lower glucose while MK-677 can worsen insulin resistance and increase appetite.
Mechanism. Opposing metabolic effects on glucose handling.
Recommendation. Do not use berberine to mask investigational-drug glucose effects; monitor glucose medically.
Effect on the composite score
If both Berberine and MK-677 (Ibutamoren) are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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