From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Alpha-lipoic acid may change glucose readings while MK-677 can impair glucose tolerance.
Mechanism. Insulin-sensitizing supplement effects plus ghrelin/GH-axis metabolic effects.
Recommendation. Use fasting glucose and A1c monitoring in any medically supervised context; avoid self-experimentation.
Stack Score
How it moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and MK-677 (Ibutamoren) are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Sevigny JJ et al. MK-677 Alzheimer randomized trial. Neurology. 2008.Needs sourceNo link