Supplement × Prescription·a caution·Emerging evidence
Melatonin may add to fatigue or somnolence in patients who are sensitive to desloratadine.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Melatonin may add to fatigue or somnolence in patients who are sensitive to desloratadine.
Mechanism. Potential additive sedative effect.
Recommendation. Use cautiously until individual alertness is known, especially with driving or fall risk.
Effect on the composite score
If both Desloratadine and Melatonin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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