Supplement × Prescription·timing-sensitive·Emerging evidence

Ezetimibe + Psyllium Husk

Timing Sensitive Emerging evidence

Psyllium can delay or reduce absorption of some oral drugs if taken at the same time as Ezetimibe.

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Substances
Pair type
Timing Sensitive
Evidence
Emerging
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
Timing SensitiveEmerging evidence

What is happening. Psyllium can delay or reduce absorption of some oral drugs if taken at the same time as Ezetimibe.

Mechanism. Gel-forming soluble fiber can trap medications in the gut and slow or reduce absorption.

Recommendation. Separate psyllium from Ezetimibe by at least 2 hours unless the prescriber gives different timing instructions.

Stack Score

How it moves the number.

Effect on the composite score

If both Ezetimibe and Psyllium Husk are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Fiber supplement drug-absorption interaction reviews.Needs sourceNo link

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