What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Fenugreek + Glyburide pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Fenugreek and Glyburide, a caution.

Q: Can I take Fenugreek and Glyburide together?

Possibly, but with caution. Fenugreek and Glyburide have a documented caution-tier interaction. Fenugreek extracts lower fasting glucose and HbA1c in type 2 diabetes meta-analyses. Glyburide is the longest-acting US sulfonylurea and already carries the highest hypoglycemia risk in its class, especially in older adults and patients with renal impairment. Adding fenugreek can produce prolonged, sometimes severe lows.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Fenugreek extracts lower fasting glucose and HbA1c in type 2 diabetes meta-analyses. Glyburide is the longest-acting US sulfonylurea and already carries the highest hypoglycemia risk in its class, especially in older adults and patients with renal impairment. Adding fenugreek can produce prolonged, sometimes severe lows.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Fenugreek and Glyburide
Pair type: Caution
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Moderate evidence

Caution

What is happening. Fenugreek extracts lower fasting glucose and HbA1c in type 2 diabetes meta-analyses. Glyburide is the longest-acting US sulfonylurea and already carries the highest hypoglycemia risk in its class, especially in older adults and patients with renal impairment. Adding fenugreek can produce prolonged, sometimes severe lows.

Mechanism. Fenugreek's 4-hydroxyisoleucine drives glucose-dependent insulin release, and its galactomannan fiber slows carbohydrate absorption. Glyburide closes pancreatic K-ATP channels to force insulin secretion. Glyburide's active metabolites accumulate in renal impairment, prolonging the hypoglycemic window.

Recommendation. Avoid starting fenugreek on glyburide unless your prescriber agrees and arranges close monitoring. If you do combine them, check fasting and bedtime glucose for at least 4 weeks and ask whether glyburide should be switched to a shorter-acting agent.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Fenugreek and Glyburide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

Check your full routine

One pair was the worked example. NutriStack runs every pair in your stack at once.

Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.

Open the interaction checker →Browse the full research index