NutriStack
Berberine and Fenugreek, a caution.
Additive glucose-lowering effect that can increase the risk of hypoglycemia, especially in people also taking antidiabetic medication.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Additive glucose-lowering effect that can increase the risk of hypoglycemia, especially in people also taking antidiabetic medication.
Mechanism. Fenugreek slows carbohydrate absorption and improves insulin sensitivity while berberine activates AMPK and reduces hepatic glucose output; the combined effect can lower blood glucose more than either alone.
Recommendation. Monitor blood glucose if combining, watch for hypoglycemia symptoms, and consult a clinician before stacking these with diabetes medications.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Berberine and Fenugreek are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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