What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Garlic Extract + Losartan pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Garlic Extract and Losartan, a synergy.

Q: Can I take Garlic Extract and Losartan together?

Yes. The combination of Garlic Extract and Losartan produces a measurable benefit. Garlic Extract lowers blood pressure modestly (approximately 4-10 mm Hg systolic in hypertensives). When combined with the ARB losartan, the effects are additive, which can help patients with uncontrolled hypertension but may produce mild hypotension if blood pressure is already at goal.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Garlic Extract lowers blood pressure modestly (approximately 4-10 mm Hg systolic in hypertensives). When combined with the ARB losartan, the effects are additive, which can help patients with uncontrolled hypertension but may produce mild hypotension if blood pressure is already at goal.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Garlic Extract and Losartan
Pair type: Synergy
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Moderate evidence

Synergy

What is happening. Garlic Extract lowers blood pressure modestly (approximately 4-10 mm Hg systolic in hypertensives). When combined with the ARB losartan, the effects are additive, which can help patients with uncontrolled hypertension but may produce mild hypotension if blood pressure is already at goal.

Mechanism. Garlic constituents inhibit ACE and promote endothelial nitric oxide production. The vasodilatory effect is complementary to AT1 receptor blockade by losartan.

Recommendation. If your blood pressure is already well controlled on losartan, monitor at home before and after starting Garlic Extract. Typical aged garlic doses are 600-1200 mg/day. Tell your prescriber so your losartan dose can be adjusted if needed.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Garlic Extract and Losartan are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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