NutriStack
Ginger Extract and Nattokinase, a caution.
Both have anticoagulant or antiplatelet activity, so combining them may increase bleeding risk, especially alongside blood-thinning medication.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Ginger Extract and Nattokinase
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 3 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both have anticoagulant or antiplatelet activity, so combining them may increase bleeding risk, especially alongside blood-thinning medication.
Mechanism. Ginger gingerols inhibit thromboxane synthesis and platelet aggregation while nattokinase has fibrinolytic activity and degrades fibrin, producing potentially additive effects on hemostasis.
Recommendation. Use caution when combining. Watch for bruising or bleeding, avoid if on anticoagulants without medical oversight, and discontinue before surgery.
Sources (3)
- Marx W et al. The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review. PLoS One. 2015;10(10):e0141119. PMID 26488162
- Weng Y et al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017;18(3). PMID 28264497
- Kurosawa Y et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601. PMID 26109079
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ginger Extract and Nattokinase are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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