NutriStack
Ginkgo Biloba and Nattokinase, a caution.
Combining ginkgo with nattokinase increases bleeding risk because both reduce the blood's tendency to clot through different mechanisms.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Ginkgo Biloba and Nattokinase
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 3 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Combining ginkgo with nattokinase increases bleeding risk because both reduce the blood's tendency to clot through different mechanisms.
Mechanism. Ginkgo terpenoids inhibit platelet-activating factor and reduce platelet aggregation, while nattokinase has fibrinolytic and antithrombotic activity that degrades fibrin, so the combined effect on hemostasis is additive.
Recommendation. Use the combination cautiously and avoid it if you take anticoagulants or antiplatelet drugs. Stop both at least 1 to 2 weeks before any surgery and report easy bruising or bleeding.
Sources (3)
- Bone KM. Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence? Mol Nutr Food Res. 2008;52(7):764-71. PMID 18214851
- Weng Y et al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017;18(3). PMID 28264497
- Kurosawa Y et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601. PMID 26109079
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ginkgo Biloba and Nattokinase are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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