NutriStack
Ginkgo Biloba and Prasugrel, a caution.
Ginkgo biloba inhibits platelet-activating factor and platelet aggregation. Added to prasugrel's potent irreversible P2Y12 inhibition, the antiplatelet effect of ginkgo creates a meaningful additive bleeding risk. Prasugrel already carries a higher bleeding rate than clopidogrel, so additional antiplatelet supplements are especially risky.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Ginkgo Biloba and Prasugrel
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Ginkgo biloba inhibits platelet-activating factor and platelet aggregation. Added to prasugrel's potent irreversible P2Y12 inhibition, the antiplatelet effect of ginkgo creates a meaningful additive bleeding risk. Prasugrel already carries a higher bleeding rate than clopidogrel, so additional antiplatelet supplements are especially risky.
Mechanism. Ginkgolides (notably ginkgolide B) are PAF antagonists that inhibit platelet aggregation. This is additive to prasugrel's irreversible blockade of platelet P2Y12 receptors.
Recommendation. Avoid ginkgo biloba while on prasugrel. If you have been combining them, stop the ginkgo and call your prescriber if you notice unusual bruising, nosebleeds, or any sign of bleeding.
Sources (2)
- Bent S, Goldberg H, Padula A, Avins AL. Spontaneous bleeding associated with ginkgo biloba: a case report and systematic review of the literature. J Gen Intern Med. 2005;20(7):657-61. PMID 16050865
- Kellermann AJ, Kloft C. Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy. 2011;31(5):490-502. PMID 21923430
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ginkgo Biloba and Prasugrel are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.