What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Garlic Extract + Prasugrel pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Garlic Extract and Prasugrel, a caution.

Q: Can I take Garlic Extract and Prasugrel together?

Possibly, but with caution. Garlic Extract and Prasugrel have a documented caution-tier interaction. Concentrated garlic supplements inhibit platelet aggregation. Combined with prasugrel's potent irreversible P2Y12 inhibition, garlic supplements stack antiplatelet activity and can raise bleeding risk, particularly perioperatively.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Concentrated garlic supplements inhibit platelet aggregation. Combined with prasugrel's potent irreversible P2Y12 inhibition, garlic supplements stack antiplatelet activity and can raise bleeding risk, particularly perioperatively.

2 primary source citations. Emerging evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Garlic Extract and Prasugrel
Pair type: Caution
Evidence (highest tier): Emerging
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Emerging evidence

Caution

What is happening. Concentrated garlic supplements inhibit platelet aggregation. Combined with prasugrel's potent irreversible P2Y12 inhibition, garlic supplements stack antiplatelet activity and can raise bleeding risk, particularly perioperatively.

Mechanism. Allicin and related thiosulfinates inhibit platelet COX activity and thromboxane synthesis, modify membrane properties, and reduce calcium signalling. These add to prasugrel's irreversible blockade of platelet P2Y12 receptors.

Recommendation. Avoid concentrated garlic supplements while on prasugrel, and stop them at least 7 days before any planned surgery. Cooking with garlic is fine.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Garlic Extract and Prasugrel are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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