From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. High-dose niacinamide and concentrated green tea extract can both raise liver-safety concerns in susceptible users.
Mechanism. Potential additive hepatic metabolic burden.
Recommendation. Avoid high-dose stacking in liver disease and stop if jaundice, dark urine, or severe fatigue occurs.
Stack Score
How it moves the number.
Effect on the composite score
If both Green Tea Extract and Niacinamide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1NIH ODS. Niacin Fact Sheet. 2024.Needs sourceNo link