NutriStack
Green Tea Extract and Rosuvastatin, a conflict.
Repeated green tea extract significantly reduced systemic rosuvastatin exposure in healthy volunteers. This could reduce or unpredictably alter rosuvastatin's lipid-lowering effect, especially with concentrated high-EGCG products. The effect may vary by transporter genetics.
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What the row says.
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At a glance
- Substances
- Green Tea Extract and Rosuvastatin
- Pair type
- Conflict
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −10 to your Stack Score (per scored conflict row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Conflict · Moderate evidence
Conflict
What is happening. Repeated green tea extract significantly reduced systemic rosuvastatin exposure in healthy volunteers. This could reduce or unpredictably alter rosuvastatin's lipid-lowering effect, especially with concentrated high-EGCG products. The effect may vary by transporter genetics.
Mechanism. Rosuvastatin depends on uptake and efflux transporters including OATP1B1 and BCRP. Green tea catechins can alter transporter activity, and a human study found about a 20% reduction in rosuvastatin exposure after repeated green tea extract.
Recommendation. Avoid starting high-dose green tea extract without checking whether your LDL response remains controlled on rosuvastatin. If you use it, keep the dose consistent and recheck lipid labs after starting, stopping, or changing the extract.
Sources (2)
- Zeng W, Hu M, Lee HK, Wat E, Lau CBS, Ho CS, et al. Effect of Green Tea Extract and Soy Isoflavones on the Pharmacokinetics of Rosuvastatin in Healthy Volunteers. Front Nutr. 2022;9:850318. PMID 35399656
- Werba JP, Misaka S, Giroli MG, Yamada S, Cavalca V, Kawabe K, et al. Overview of green tea interaction with cardiovascular drugs. Curr Pharm Des. 2015;21(9):1213-1219. PMID 25312732
Stack Score
How this pair moves the number.
Effect on the composite score
If both Green Tea Extract and Rosuvastatin are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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