NutriStack
Hydroxychloroquine and Magnesium Glycinate, a caution.
Hydroxychloroquine can prolong QTc, and low magnesium makes torsades de pointes more likely when QT risk factors stack. Magnesium supplementation should be viewed as deficiency prevention or repletion, not as a booster for hydroxychloroquine. High-dose magnesium can cause diarrhea and can accumulate in significant kidney disease.
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At a glance
- Substances
- Hydroxychloroquine and Magnesium Glycinate
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Hydroxychloroquine can prolong QTc, and low magnesium makes torsades de pointes more likely when QT risk factors stack. Magnesium supplementation should be viewed as deficiency prevention or repletion, not as a booster for hydroxychloroquine. High-dose magnesium can cause diarrhea and can accumulate in significant kidney disease.
Mechanism. Magnesium helps stabilize cardiac repolarization and suppress early afterdepolarizations. Hypomagnesemia lowers repolarization reserve and often worsens potassium repletion, increasing vulnerability to drug-induced torsades.
Recommendation. Maintain normal magnesium status while taking hydroxychloroquine, especially if you use diuretics, proton pump inhibitors, or have chronic diarrhea. Ask your clinician whether magnesium should be checked if you have arrhythmia symptoms or multiple QT-risk medicines. Do not use high-dose magnesium if kidney function is reduced unless it is being monitored.
Sources (2)
- Agstam S, Yadav A, Kumar-M P, Gupta A. Hydroxychloroquine and QTc prolongation in patients with COVID-19: A systematic review and meta-analysis. Indian Pacing Electrophysiol J. 2021;21(1):36-43. PMID 33075484
- Tisdale JE. Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management. Can Pharm J (Ott). 2016;149(3):139-152. PMID 27212965
Stack Score
How this pair moves the number.
Effect on the composite score
If both Hydroxychloroquine and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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