NutriStack
Insulin Aspart and Vanadium, a caution.
Vanadium has insulin-like signaling effects and has lowered glucose or improved insulin sensitivity in small human diabetes studies. Insulin aspart is a rapid-acting mealtime insulin, so adding vanadium can make post-dose hypoglycemia more likely if carbohydrate intake, exercise, illness, or insulin dosing is not adjusted.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Insulin Aspart and Vanadium
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 3 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Vanadium has insulin-like signaling effects and has lowered glucose or improved insulin sensitivity in small human diabetes studies. Insulin aspart is a rapid-acting mealtime insulin, so adding vanadium can make post-dose hypoglycemia more likely if carbohydrate intake, exercise, illness, or insulin dosing is not adjusted.
Mechanism. Vanadium compounds can improve insulin signaling and glucose disposal. Insulin aspart acutely increases peripheral glucose uptake and suppresses hepatic glucose output, so vanadium may add to the same pharmacodynamic pathway.
Recommendation. Do not combine vanadium with insulin aspart unless your diabetes clinician is monitoring the change. Check glucose more frequently around meals and activity when vanadium is started, stopped, or dose-adjusted. Treat low glucose promptly and seek urgent help for severe neuroglycopenic symptoms.
Sources (3)
- Cusi K, Cukier S, DeFronzo RA, Torres M, Puchulu FM, Redondo JC. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab. 2001;86(3):1410-1417. PMID 11238540
- Goldfine AB, Patti ME, Zuberi L, et al. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism. 2000;49(3):400-410. PMID 10726921
- Amiel SA, Dixon T, Mann R, Jameson K. Hypoglycaemia in Type 2 diabetes. Diabet Med. 2008;25(3):245-254. PMID 18215172
Stack Score
How this pair moves the number.
Effect on the composite score
If both Insulin Aspart and Vanadium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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