NutriStack
Iron and Zinc Picolinate, a conflict.
Iron and zinc picolinate compete for the same absorption pathways when taken together in supplement form.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Iron and Zinc Picolinate
- Pair type
- Conflict
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- −10 to your Stack Score (per scored conflict row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Conflict · Strong evidence
Conflict
What is happening. Iron and zinc picolinate compete for the same absorption pathways when taken together in supplement form.
Mechanism. Both divalent cations compete for DMT1 and ZIP4 transporters in enterocytes. High-dose iron (>25mg) can reduce zinc picolinate absorption by 50%.
Recommendation. Take iron and zinc picolinate at different times of day, separated by at least 2 hours.
Minimum separation. 120
Stack Score
How this pair moves the number.
Effect on the composite score
If both Iron and Zinc Picolinate are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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