NutriStack
Lisinopril and Zinc Picolinate, a caution.
ACE inhibitors as a class increase urinary zinc excretion and lower intracellular zinc over months of use. Zinc Picolinate is a well-absorbed form often used to correct this kind of subclinical deficiency. Symptoms include altered taste, slow wound healing, hair loss, and reduced immune function.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Lisinopril and Zinc Picolinate
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. ACE inhibitors as a class increase urinary zinc excretion and lower intracellular zinc over months of use. Zinc Picolinate is a well-absorbed form often used to correct this kind of subclinical deficiency. Symptoms include altered taste, slow wound healing, hair loss, and reduced immune function.
Mechanism. ACE inhibitors complex with zinc and increase its renal excretion. Picolinate enhances zinc absorption and bioavailability, helping to offset the loss.
Recommendation. If you take lisinopril long term, Zinc Picolinate 15-30 mg/day with food is a reasonable maintenance strategy, especially if you have altered taste or recurrent infections. Have your prescriber check zinc status if you suspect deficiency rather than dosing higher empirically.
Sources (2)
- Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013;67(8):717-25. PMID 23279674
- Golik A, Modai D, Averbukh Z, Sheffy M, Shamis A, Cohen N, Shaked U, Dolev E. Zinc metabolism in patients treated with captopril versus enalapril. Metabolism. 1990;39(7):665-7. PMID 2195291
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lisinopril and Zinc Picolinate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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