NutriStack
Enalapril and Zinc Picolinate, a caution.
Enalapril increases urinary zinc excretion and lowers intracellular zinc over months of use. Zinc Picolinate is a well-absorbed form often used to correct this kind of subclinical deficiency. Symptoms of zinc deficiency include altered taste, slow wound healing, hair loss, and reduced immune function.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Enalapril and Zinc Picolinate
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Enalapril increases urinary zinc excretion and lowers intracellular zinc over months of use. Zinc Picolinate is a well-absorbed form often used to correct this kind of subclinical deficiency. Symptoms of zinc deficiency include altered taste, slow wound healing, hair loss, and reduced immune function.
Mechanism. ACE inhibitors complex with zinc and increase its renal excretion, depleting intracellular zinc pools. Picolinate enhances zinc absorption and bioavailability, helping to offset this loss.
Recommendation. If you take enalapril long term, consider Zinc Picolinate 15-30 mg/day with food, especially if you have altered taste or recurrent infections. Have your prescriber check zinc status if you suspect deficiency rather than dosing higher empirically.
Sources (2)
- Golik A, Zaidenstein R, Dishi V, Blatt A, Cohen N, Cotter G, Berman S, Weissgarten J. Effects of captopril and enalapril on zinc metabolism in hypertensive patients. J Am Coll Nutr. 1998;17(1):75-8. PMID 9477394
- Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. Int J Clin Pract. 2013;67(8):717-25. PMID 23279674
Stack Score
How this pair moves the number.
Effect on the composite score
If both Enalapril and Zinc Picolinate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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