NutriStack
Coenzyme Q10 and Enalapril, a synergy.
Coenzyme Q10 lowers blood pressure modestly through improved endothelial function and reduced oxidative stress. A clinical study using CoQ10 as a component of combination therapy with enalapril found improved 24-hour blood pressure control and better endothelial function compared with enalapril alone. The combination is generally additive and well tolerated.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Coenzyme Q10 and Enalapril
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Coenzyme Q10 lowers blood pressure modestly through improved endothelial function and reduced oxidative stress. A clinical study using CoQ10 as a component of combination therapy with enalapril found improved 24-hour blood pressure control and better endothelial function compared with enalapril alone. The combination is generally additive and well tolerated.
Mechanism. CoQ10 improves mitochondrial function in vascular smooth muscle and endothelium and reduces oxidative inactivation of nitric oxide, complementing ACE inhibition. Animal data also suggest CoQ10 prolongs the duration of enalapril's hypotensive effect.
Recommendation. If your blood pressure is well controlled on enalapril alone, monitor at home before adding CoQ10. A typical dose is 100-200 mg/day with a fat-containing meal. Recheck blood pressure within 2-4 weeks and tell your prescriber so any enalapril dose adjustment can be made.
Sources (2)
- Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007;21(4):297-306. PMID 17287847
- Mikhin VP, Kharchenko AV, Rosliakova EA, Cherniatina MA. Application of coenzyme Q(10) in combination therapy of arterial hypertension. Kardiologiia. 2011;51(6):26-31. PMID 21878067
Stack Score
How this pair moves the number.
Effect on the composite score
If both Coenzyme Q10 and Enalapril are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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