NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Enalapril

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Enalapril is an ACE inhibitor prodrug with landmark evidence from the SOLVD trial demonstrating mortality reduction in heart failure with reduced ejection fraction. It is widely used for hypertension, heart failure, and asymptomatic left ventricular dysfunction.

Evidence tier
Strong
Indexed sources
10 1985–2023
Interactions
0
Depletes
1 nutrient
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Enalapril is an ACE inhibitor prodrug with landmark evidence from the SOLVD trial demonstrating mortality reduction in heart failure with reduced ejection fraction. NutriStack rates the supporting evidence as strong. Common adult dosing is 2.5–40 mg daily in 1–2 divided doses (as prescribed by your physician), though a prescriber sets the actual dose. With long-term use it can deplete zinc. This profile indexes 10 sources.

What it's good for
  • Reduces mortality in heart failure with reduced ejection fraction7,8
  • Lowers blood pressure effectively
  • Prevents cardiac remodeling after MI
  • Available in IV form (enalaprilat) for hypertensive urgency2
What to watch for
  • Dry cough
  • Hyperkalemia
  • Dizziness and hypotension
  • History of angioedema with ACE inhibitors
  • Pregnancy

The bottom line

Evidence rating strong. Most-documented uses: reduces mortality in heart failure with reduced ejection fraction, lowers blood pressure effectively, prevents cardiac remodeling after mi. 10 sources indexed (1985–2023), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Prodrug hydrolyzed in the liver to enalaprilat, the active ACE inhibitor. Enalaprilat inhibits angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. This reduces peripheral vascular resistance, aldosterone secretion, and cardiac remodeling. Also inhibits bradykinin degradation.2

Class
ACE Inhibitor
Dosing

Dosing & protocol.

Common range
2.5–40 mg daily in 1–2 divided doses (as prescribed by your physician)
Recommended form
Oral tablet

Can be taken with or without food; prodrug requires hepatic conversion to active enalaprilat4

Depletions

What it depletes.

Nutrients this medication can lower over time, and what to replace.

Zinc

Mild

ACE inhibition has been associated with increased urinary zinc excretion and altered taste in some long-term users.

Replace Zinc PicolinateMonitor Serum zincOnset Usually over weeks to months

Full Enalapril depletion and interaction guide →

Safety

Full safety detail.

Side effects

  • Dry cough
  • Hyperkalemia
  • Dizziness and hypotension
  • Headache
  • Angioedema (rare)
  • Fatigue
  • Renal impairment

Contraindications

  • History of angioedema with ACE inhibitors
  • Pregnancy
  • Bilateral renal artery stenosis9
  • Concurrent use with aliskiren in diabetic patients
  • Concurrent sacubitril/valsartan (within 36 hours)1
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

5

Reviews & position papers

1

Reference material

4
FAQ

Common questions.

Quick answers about Enalapril, drawn from the data on this page.

What is Enalapril?

Enalapril is an ACE inhibitor prodrug with landmark evidence from the SOLVD trial demonstrating mortality reduction in heart failure with reduced ejection fraction. It is widely used for hypertension, heart failure, and asymptomatic left ventricular dysfunction.

What is Enalapril used for?

Commonly cited benefits of Enalapril include: Reduces mortality in heart failure with reduced ejection fraction; Lowers blood pressure effectively; Prevents cardiac remodeling after MI; Available in IV form (enalaprilat) for hypertensive urgency. NutriStack rates the overall evidence as strong.

What is a typical dose of Enalapril?

A typical adult dose of Enalapril is 2.5–40 mg daily in 1–2 divided doses (as prescribed by your physician). The commonly recommended form is Oral tablet. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Enalapril?

Reported side effects include dry cough, hyperkalemia, dizziness and hypotension, headache, angioedema (rare), fatigue. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Enalapril?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Enalapril in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.