Medication·Interactions & depletion·Reviewed June 9, 2026
Enalapril interactions.
Enalapril has 7 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Zinc. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Enalapril at a glance.
A quick, data-grounded summary. The full tables are below.
Enalapril has 7 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Zinc. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with enalapril.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Potassium | Conflict | Enalapril reduces aldosterone, decreasing potassium excretion. Potassium supplements significantly increase hyperkalemia risk. |
| Lithium Orotate | Caution | Enalapril reduces sodium reabsorption and lowers glomerular filtration, which causes the kidney to retain lithium and pushes serum lithium levels... details → |
| Zinc | Caution | Enalapril increases urinary zinc excretion and lowers intracellular zinc in monocytes over months of use. In a 6-month controlled study of... details → |
| Zinc Picolinate | Caution | Enalapril increases urinary zinc excretion and lowers intracellular zinc over months of use. Zinc Picolinate is a well-absorbed form often used to... details → |
| Coenzyme Q10 | Synergy | Coenzyme Q10 lowers blood pressure modestly through improved endothelial function and reduced oxidative stress. A clinical study using CoQ10 as a... details → |
| Garlic Extract | Synergy | Garlic Extract lowers blood pressure modestly and has independent ACE-inhibitory activity in vitro. When combined with enalapril the effects are... details → |
| Quercetin | Synergy | Quercetin lowers blood pressure modestly (about 5-7 mm Hg systolic in stage 1 hypertensives) through endothelial improvement, AT1 receptor... details → |
What enalapril can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Zinc | Mild | ACE inhibition has been associated with increased urinary zinc excretion and altered taste in some long-term users. | Zinc Picolinate | Serum zinc |
The full enalapril profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common enalapril questions.
Quick answers drawn from the tables above.
What interacts with Enalapril?
In the NutriStack database, Enalapril has 7 documented interactions. The most notable include Potassium, Lithium Orotate, Zinc, Zinc Picolinate, and Coenzyme Q10. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Enalapril?
Enalapril is flagged against 1 substance in the database, including Potassium. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Enalapril deplete any nutrients?
Enalapril is associated with lowering Zinc with prolonged use. Useful biomarkers to monitor include Serum zinc. Ask your prescriber before adding any replacement supplement.
Is it safe to take Potassium with Enalapril?
NutriStack classifies the Potassium and Enalapril pairing as conflict: Enalapril reduces aldosterone, decreasing potassium excretion. Potassium supplements significantly increase hyperkalemia risk. Avoid potassium supplements on enalapril unless prescribed with monitoring. Avoid potassium salt substitutes. Always confirm with your prescriber.
Check your whole stack
See how enalapril fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.