Lisinopril
Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Lisinopril is a long-acting ACE inhibitor widely used for hypertension, heart failure, and post-myocardial infarction care. It is one of the most commonly prescribed antihypertensives and has demonstrated mortality benefits in heart failure and diabetic nephropathy.
Exploratory record, not a reviewed medical publication.
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This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Lisinopril is a long-acting ACE inhibitor widely used for hypertension, heart failure, and post-myocardial infarction care. NutriStack rates the supporting evidence as strong. Common adult dosing is 5–40 mg once daily (as prescribed by your physician), though a prescriber sets the actual dose. With long-term use it can deplete zinc. This profile indexes 11 sources.
The bottom line
Evidence rating strong. Most-documented uses: lowers blood pressure effectively, reduces mortality in heart failure (atlas trial), protects kidney function in diabetic nephropathy. 11 sources indexed (2017–2023), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Inhibits angiotensin-converting enzyme (ACE), preventing conversion of angiotensin I to angiotensin II. This reduces vasoconstriction, aldosterone secretion, and sympathetic nervous system activity. Also inhibits bradykinin degradation, contributing to vasodilation and the characteristic dry cough side effect.1,8
Dosing & protocol.
Can be taken with or without food; does not require hepatic activation (active drug)
What it depletes.
Nutrients this medication can lower over time, and what to replace.
Zinc
MildACE inhibition has been associated with increased urinary zinc excretion and altered taste in some long-term users.
Full safety detail.
Side effects
- Dry cough (up to 10–15% of patients)
- Hyperkalemia
- Dizziness and hypotension
- Headache
- Angioedema (rare but potentially life-threatening)
- Fatigue
- Acute kidney injury (especially with volume depletion)
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
3- 1Angiotensin-converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta-analysisPMIDHu Y, Liang L, Liu S, Kung JY et al. · Journal of Clinical Hypertension (Greenwich) · 2023
ACE inhibitors, including lisinopril, significantly increased the risk of cough compared to placebo (OR ~3.0) and other antihypertensive classes, while remaining highly effective for blood pressure reduction
- 2Pharmacological Treatment of Arterial Hypertension in Children and Adolescents: A Network Meta-AnalysisPMIDBurrello J, Erhardt EM, Saint-Hilary G, Veglio F et al. · Hypertension · 2018
ACE inhibitors were among the most effective drug classes for reducing systolic and diastolic blood pressure in hypertensive children and adolescents
- 3An evidence-based systematic review of the off-label uses of lisinoprilPMIDSadat-Ebrahimi SR, Parnianfard N, Vahed N et al. · British journal of clinical pharmacology · 2018
Sadat-Ebrahimi SR, Parnianfard N, Vahed N et al.. An evidence-based systematic review of the off-label uses of lisinopril. British journal of clinical pharmacology. 2018
Randomized controlled trials
4- 4Oral combined hydrochlorothiazide and lisinopril vs nifedipine for postpartum hypertension: a comparative-effectiveness pilot randomized controlled trialPMIDFishel Bartal M, Blackwell SC, Pedroza C et al. · American journal of obstetrics and gynecology · 2023
Fishel Bartal M, Blackwell SC, Pedroza C et al.. Oral combined hydrochlorothiazide and lisinopril vs nifedipine for postpartum hypertension: a comparative-effectiveness pilot randomized controlled trial. American journal of obstetrics and gynecology. 2023
- 5Randomized Trial of Lisinopril Versus Carvedilol to Prevent Trastuzumab Cardiotoxicity in Patients With Breast CancerPMIDGuglin M, Krischer J, Tamura R et al. · Journal of the American College of Cardiology · 2019
Guglin M, Krischer J, Tamura R et al.. Randomized Trial of Lisinopril Versus Carvedilol to Prevent Trastuzumab Cardiotoxicity in Patients With Breast Cancer. Journal of the American College of Cardiology. 2019
- 6Lisinopril versus lisinopril and losartan for mild childhood IgA nephropathy: a randomized controlled trial (JSKDC01 study)PMIDShima Y, Nakanishi K, Sako M et al. · Pediatric nephrology (Berlin, Germany) · 2019
Shima Y, Nakanishi K, Sako M et al.. Lisinopril versus lisinopril and losartan for mild childhood IgA nephropathy: a randomized controlled trial (JSKDC01 study). Pediatric nephrology (Berlin, Germany). 2019
- 7A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected IndividualsPMIDCockerham LR, Yukl SA, Harvill K et al. · Pathogens & immunity · 2017
Cockerham LR, Yukl SA, Harvill K et al.. A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals. Pathogens & immunity. 2017
Reference material
4- 8Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients (HOPE). N Engl J Med. 2000.Source linkedPMID
- 9SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991.Source linkedPMID
- 10Singh A et al. Efficacy of pharmacological agents for management of post-partum hypertension: A systematic review and network meta-analysis. J Hum Hypertens. 2026.Source linkedPMID
- 11Olvera Lopez E, Parmar M, Pendela VS et al.. Lisinopril. 2026Source linkedPMID
Common questions.
Quick answers about Lisinopril, drawn from the data on this page.
What is Lisinopril?
Lisinopril is a long-acting ACE inhibitor widely used for hypertension, heart failure, and post-myocardial infarction care. It is one of the most commonly prescribed antihypertensives and has demonstrated mortality benefits in heart failure and diabetic nephropathy.
What is Lisinopril used for?
Commonly cited benefits of Lisinopril include: Lowers blood pressure effectively; Reduces mortality in heart failure (ATLAS trial); Protects kidney function in diabetic nephropathy; Reduces left ventricular remodeling post-MI. NutriStack rates the overall evidence as strong.
What is a typical dose of Lisinopril?
A typical adult dose of Lisinopril is 5–40 mg once daily (as prescribed by your physician). The commonly recommended form is Oral tablet. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Lisinopril?
Reported side effects include dry cough (up to 10–15% of patients), hyperkalemia, dizziness and hypotension, headache, angioedema (rare but potentially life-threatening), fatigue. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Lisinopril?
NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Lisinopril in NutriStack.
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