Medication·Interactions & depletion·Reviewed June 9, 2026
Lisinopril interactions.
Lisinopril has 21 documented interactions in the NutriStack database. Prolonged use is also associated with lower Zinc. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Lisinopril at a glance.
A quick, data-grounded summary. The full tables are below.
Lisinopril has 21 documented interactions in the NutriStack database. Prolonged use is also associated with lower Zinc. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with lisinopril.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Lithium | Caution | ACE inhibitors reduce renal lithium clearance, potentially increasing lithium levels by 25-40% and causing lithium toxicity. Symptoms include... details → |
| Potassium | Caution | ACE inhibitors like lisinopril reduce aldosterone secretion, which decreases renal potassium excretion and raises serum potassium. Additional... details → |
| Spironolactone | Caution | Both ACE inhibitors and spironolactone increase serum potassium through different mechanisms. Combined use significantly increases the risk of... details → |
| Zinc | Caution | ACE inhibitors as a class increase urinary zinc excretion and lower intracellular zinc over months of use. A systematic review of zinc and... details → |
| Zinc Picolinate | Caution | ACE inhibitors as a class increase urinary zinc excretion and lower intracellular zinc over months of use. Zinc Picolinate is a well-absorbed form... details → |
| Iron | Timing Sensitive | Iron supplements may modestly reduce the absorption of ACE inhibitors when taken simultaneously. While the interaction is minor compared to other... |
| Alpha-Lipoic Acid | Synergy | Alpha-Lipoic Acid lowers blood pressure modestly and improves endothelial function. The QUALITY study found that the blood pressure and endothelial... |
| Coenzyme Q10 | Synergy | Coenzyme Q10 lowers blood pressure modestly through improved endothelial function and reduced oxidative stress. A meta-analysis of 12 clinical... details → |
| Fish Oil | Synergy | Fish Oil reduces blood pressure modestly (about 3/1.5 mm Hg in hypertensives) and has independent renoprotective effects through suppression of ACE... details → |
| Garlic Extract | Synergy | Garlic Extract lowers blood pressure modestly (approximately 4-10 mm Hg systolic in hypertensives) and has independent ACE-inhibitory activity in... details → |
| Grape Seed Extract | Synergy | Grape Seed Extract lowers blood pressure modestly (about 6 mm Hg systolic and 3 mm Hg diastolic in meta-analyses) through improved endothelial... details → |
| L-Arginine | Synergy | L-Arginine is the substrate for endothelial nitric oxide synthase, and oral supplementation produces modest blood pressure reductions (about 5 mm Hg... details → |
| L-Citrulline | Synergy | L-Citrulline is converted to arginine in the kidney and produces sustained increases in nitric oxide. A meta-analysis of clinical trials reported... details → |
| Magnesium Citrate | Synergy | Magnesium supplementation lowers blood pressure modestly, with meta-analyses reporting about 2-3 mm Hg systolic and 2 mm Hg diastolic reductions in... details → |
| Magnesium Taurate | Synergy | Magnesium supplementation lowers blood pressure modestly, with meta-analyses reporting about 2-3 mm Hg systolic reductions in hypertensives. The... details → |
| NAC | Synergy | NAC has direct ACE-inhibitory activity (about 30% reduction in ACE activity in vivo) and provides sulfhydryl groups that may amplify... |
| Olive Leaf Extract | Synergy | Olive Leaf Extract lowers blood pressure (about 4-11 mm Hg systolic depending on dose) and was non-inferior to captopril for stage 1 hypertension in... details → |
| Quercetin | Synergy | Quercetin lowers blood pressure modestly (about 5-7 mm Hg systolic in stage 1 hypertensives) through endothelial improvement, AT1 receptor... details → |
| Spirulina | Synergy | Spirulina lowers blood pressure modestly in adults (about 3-5 mm Hg systolic and 3-4 mm Hg diastolic in meta-analyses). It also contains meaningful... details → |
| Taurine | Synergy | Taurine lowers blood pressure in prehypertensive and hypertensive adults (about 7 mm Hg systolic in randomized trials) and reduces sympathetic... details → |
| Vitamin D3 | Synergy | Vitamin D directly suppresses renin biosynthesis, so vitamin D deficiency leaves the renin-angiotensin system over-activated. Correcting deficiency... details → |
What lisinopril can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Zinc | Mild | ACE inhibition has been associated with increased urinary zinc excretion and altered taste in some long-term users. | Zinc Picolinate | Serum zinc |
The full lisinopril profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common lisinopril questions.
Quick answers drawn from the tables above.
What interacts with Lisinopril?
In the NutriStack database, Lisinopril has 21 documented interactions. The most notable include Lithium, Potassium, Spironolactone, Zinc, and Zinc Picolinate. Check any specific combination before taking it and confirm with your prescriber.
Does Lisinopril deplete any nutrients?
Lisinopril is associated with lowering Zinc with prolonged use. Useful biomarkers to monitor include Serum zinc. Ask your prescriber before adding any replacement supplement.
Is it safe to take Lithium with Lisinopril?
NutriStack classifies the Lithium and Lisinopril pairing as caution: ACE inhibitors reduce renal lithium clearance, potentially increasing lithium levels by 25-40% and causing lithium toxicity. Symptoms include tremor, nausea, confusion,... Monitor lithium levels closely when starting, stopping, or adjusting ACE inhibitor dose. Reduce lithium dose as needed. Watch for toxicity symptoms. Always confirm with your prescriber.
Check your whole stack
See how lisinopril fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.