What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Lisinopril + Zinc pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Lisinopril and Zinc, a caution.

Q: Can I take Lisinopril and Zinc together?

Possibly, but with caution. Lisinopril and Zinc have a documented caution-tier interaction. ACE inhibitors as a class increase urinary zinc excretion and lower intracellular zinc over months of use. A systematic review of zinc and antihypertensive therapy identified depletion across multiple ACE inhibitors, with lisinopril patients showing similar patterns of altered zinc status. Symptoms of zinc deficiency include altered taste, slow wound healing, hair loss, and reduced immune function.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

ACE inhibitors as a class increase urinary zinc excretion and lower intracellular zinc over months of use. A systematic review of zinc and antihypertensive therapy identified depletion across multiple ACE inhibitors, with lisinopril patients showing similar patterns of altered zinc status. Symptoms of zinc deficiency include altered taste, slow wound healing, hair loss, and reduced immune function.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Lisinopril and Zinc
Pair type: Caution
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Moderate evidence

Caution

What is happening. ACE inhibitors as a class increase urinary zinc excretion and lower intracellular zinc over months of use. A systematic review of zinc and antihypertensive therapy identified depletion across multiple ACE inhibitors, with lisinopril patients showing similar patterns of altered zinc status. Symptoms of zinc deficiency include altered taste, slow wound healing, hair loss, and reduced immune function.

Mechanism. ACE inhibitors complex with zinc and increase its renal excretion. Chronic use depletes intracellular zinc pools even when serum zinc looks normal.

Recommendation. If you take lisinopril long term, consider a modest zinc supplement (15-30 mg/day) or a multivitamin containing zinc, especially if you notice loss of taste or recurrent infections. Take zinc with food to limit GI upset.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Lisinopril and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

Check your full routine

One pair was the worked example. NutriStack runs every pair in your stack at once.

Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.

Open the interaction checker →Browse the full research index