NutriStack
L-Theanine and Passionflower, a synergy.
Both calm the nervous system mainly through GABA pathways, so combining them can produce additive anxiety-reducing and sleep-supporting effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- L-Theanine and Passionflower
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Both calm the nervous system mainly through GABA pathways, so combining them can produce additive anxiety-reducing and sleep-supporting effects.
Mechanism. L-theanine raises GABA and alpha-wave activity, while passionflower flavonoids modulate GABA-A receptors and affect GABA reuptake, giving overlapping GABAergic calming effects.
Recommendation. May be combined for daytime calm or sleep support. Start with standard single doses of each and watch for additive drowsiness, especially if also using sedatives.
Sources (2)
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Theanine and Passionflower are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.