NutriStack
Lansoprazole and Zinc, a caution.
Long-term lansoprazole therapy reduces zinc absorption and lowers body zinc stores. Controlled data on PPI users showed plasma zinc rose only 37% with supplementation compared with 126% in controls, and baseline zinc was about 28% lower in PPI users. Reduced zinc can impair immunity, taste, and wound healing.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Lansoprazole and Zinc
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Long-term lansoprazole therapy reduces zinc absorption and lowers body zinc stores. Controlled data on PPI users showed plasma zinc rose only 37% with supplementation compared with 126% in controls, and baseline zinc was about 28% lower in PPI users. Reduced zinc can impair immunity, taste, and wound healing.
Mechanism. Zinc absorption depends in part on gastric acid to solubilize zinc salts and on intestinal ZIP4 transporters that perform best in an acidic luminal environment. Lansoprazole's suppression of gastric acid blunts both steps.
Recommendation. If you take lansoprazole long-term, consider 15-30 mg/day of zinc, preferably as zinc picolinate or bisglycinate, which are less acid-dependent. Take with food if it causes nausea.
Sources (2)
- Farrell CP, Morgan M, Rudolph DS, et al. Proton Pump Inhibitors Interfere With Zinc Absorption and Zinc Body Stores. Gastroenterol Res. 2011;4(6):243-51. PMID 27957023
- Freedberg DE, Kim LS, Yang YX. The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association. Gastroenterology. 2017;152(4):706-15. PMID 28257716
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lansoprazole and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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