Supplement × Prescription·contraindicated·Moderate evidence
St. John's Wort can increase serotonergic activity and can induce drug-metabolizing pathways.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort can increase serotonergic activity and can induce drug-metabolizing pathways.
Mechanism. Serotonergic activity increases serotonin toxicity risk; CYP3A4 induction may complicate exposure to levomilnacipran and other drugs.
Recommendation. Do not combine St. John's Wort with levomilnacipran.
Effect on the composite score
If both Levomilnacipran and St. John's Wort are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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