NutriStack
Magnesium Glycinate and Pregnenolone, a synergy.
Pregnenolone is a neurosteroid that modulates GABA receptors and magnesium glycinate supports relaxation and sleep, so the pair may complementarily support calm and sleep quality.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Magnesium Glycinate and Pregnenolone
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Pregnenolone is a neurosteroid that modulates GABA receptors and magnesium glycinate supports relaxation and sleep, so the pair may complementarily support calm and sleep quality.
Mechanism. Pregnenolone and its metabolites act as neurosteroids influencing GABA-A receptor signaling, while magnesium contributes to NMDA receptor regulation and GABAergic tone, giving complementary calming effects on the central nervous system.
Recommendation. Can be taken together, ideally in the evening if sleep and relaxation are the goal; start with conservative doses.
Sources (2)
- Reddy DS, Neurosteroids: endogenous role in the human brain and therapeutic potentials, Progress in Brain Research, 2010
- Boyle NB et al, The effects of magnesium supplementation on subjective anxiety and stress, Nutrients, 2017
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Glycinate and Pregnenolone are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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