NutriStack
Magnesium Glycinate and Ranolazine, a synergy.
Ranolazine can prolong the QT interval, and torsades risk rises when magnesium is low. Maintaining normal magnesium helps stabilize repolarization and supports potassium balance. Oral magnesium is preventive support for deficiency risk, not a substitute for emergency treatment of an arrhythmia.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Magnesium Glycinate and Ranolazine
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 3 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Ranolazine can prolong the QT interval, and torsades risk rises when magnesium is low. Maintaining normal magnesium helps stabilize repolarization and supports potassium balance. Oral magnesium is preventive support for deficiency risk, not a substitute for emergency treatment of an arrhythmia.
Mechanism. Ranolazine has IKr-blocking activity that can prolong repolarization. Hypomagnesemia promotes early afterdepolarizations and makes drug-induced QT prolongation more likely to become torsades.
Recommendation. Maintain adequate magnesium intake while taking ranolazine, especially if you use diuretics, PPIs, or have chronic diarrhea. Ask your prescriber about checking magnesium if you have arrhythmia symptoms or risk factors, and avoid high-dose magnesium if kidney function is reduced unless monitored.
Sources (3)
- Liu Z, Williams RB, Rosen BD. The potential contribution of ranolazine to Torsade de Pointe. J Cardiovasc Dis Res. 2013;4(3):187-190. PMID 24396259
- Schram G, Zhang L, Derakhchan K, Ehrlich JR, Belardinelli L, Nattel S. Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects. Br J Pharmacol. 2004;142(8):1300-1308. PMID 15277312
- Tisdale JE. Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management. Can Pharm J (Ott). 2016;149(3):139-152. PMID 27212965
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Glycinate and Ranolazine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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