NutriStack
Magnesium Glycinate and Rhodiola Rosea, a synergy.
Magnesium supports the stress response and nervous system relaxation, complementing rhodiola's adaptogenic effect on stress and fatigue.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Magnesium Glycinate and Rhodiola Rosea
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Magnesium supports the stress response and nervous system relaxation, complementing rhodiola's adaptogenic effect on stress and fatigue.
Mechanism. Chronic stress depletes magnesium, and magnesium regulates HPA axis activity and NMDA receptor tone to dampen stress reactivity, while rhodiola normalizes cortisol and stress-hormone signaling, so the two address the stress response from complementary angles.
Recommendation. Reasonable to combine. Take rhodiola earlier in the day for its activating effect and magnesium glycinate in the evening to support relaxation and sleep.
Sources (2)
- Pickering G, Mazur A, Trousselard M, et al. Magnesium status and stress: the vicious circle concept revisited. Nutrients. 2020
- Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Glycinate and Rhodiola Rosea are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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