What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Magnesium Glycinate + Sodium Butyrate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·timing-sensitive·Insufficient evidence

Magnesium Glycinate + Sodium Butyrate

Q: Can I take Magnesium Glycinate and Sodium Butyrate together?

Yes, if you separate them in time. Magnesium Glycinate and Sodium Butyrate have a documented timing-sensitive interaction. Both supplements can loosen stools at higher intakes, magnesium via an osmotic effect and butyrate via effects on bowel habit. Taken together at full doses, they may compound GI laxative effects in sensitive individuals.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Insufficient evidence

Both supplements can loosen stools at higher intakes, magnesium via an osmotic effect and butyrate via effects on bowel habit. Taken together at full doses, they may compound GI laxative effects in sensitive individuals.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Magnesium Glycinate and Sodium Butyrate

Pair type

Timing Sensitive

Evidence

Insufficient

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

Timing SensitiveInsufficient evidence

What is happening. Both supplements can loosen stools at higher intakes, magnesium via an osmotic effect and butyrate via effects on bowel habit. Taken together at full doses, they may compound GI laxative effects in sensitive individuals.

Mechanism. Additive effects on intestinal motility and stool water content, with magnesium acting osmotically and butyrate influencing colonic transit and secretion.

Recommendation. If loose stools occur, reduce the magnesium dose or stagger the two across the day, and titrate each separately to find a tolerable level.

Stack Score

How it moves the number.

Effect on the composite score

If both Magnesium Glycinate and Sodium Butyrate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Mori S, et al. Magnesium oxide in constipation: clinical considerations of osmotic laxatives. Nutrients. 2021.Needs sourceNo link

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Open the interaction checker → Browse the research index