NutriStack
Magnesium Glycinate and Sotalol, a synergy.
Sotalol prolongs the QT interval and can cause torsades de pointes, with the risk amplified by low magnesium. Magnesium supplementation helps maintain normal magnesium levels and reduces arrhythmia risk; intravenous magnesium is a first-line treatment for sotalol-related torsades.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Magnesium Glycinate and Sotalol
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Sotalol prolongs the QT interval and can cause torsades de pointes, with the risk amplified by low magnesium. Magnesium supplementation helps maintain normal magnesium levels and reduces arrhythmia risk; intravenous magnesium is a first-line treatment for sotalol-related torsades.
Mechanism. Sotalol blocks the IKr potassium channel, prolonging cardiac repolarization. Hypomagnesemia further destabilizes repolarization by impairing IKs and Na/K-ATPase function, raising the risk of early afterdepolarizations and torsades de pointes.
Recommendation. Maintain magnesium intake (e.g., 200-350 mg/day supplemental elemental magnesium from magnesium glycinate) while on sotalol, and report any signs of arrhythmia (palpitations, fainting, dizziness) to your prescriber immediately. Have magnesium levels checked periodically, especially if you take diuretics.
Sources (2)
- Soyka LF, Wirtz C, Spangenberg RB. Clinical safety profile of sotalol in patients with arrhythmias. Am J Cardiol. 1990;65(2):74A-81A. PMID 2403737
- Makkar RR, Fromm BS, Steinman RT, Meissner MD, Lehmann MH. Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. JAMA. 1993;270(21):2590-7. PMID 8230644
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Glycinate and Sotalol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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