What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Magnesium Glycinate + Vancomycin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·a caution·Emerging evidence

Magnesium Glycinate + Vancomycin

Q: Can I take Magnesium Glycinate and Vancomycin together?

Possibly, but with caution. Magnesium Glycinate and Vancomycin have a documented caution-tier interaction. Intravenous vancomycin is nephrotoxic, particularly at high troughs or with prolonged courses, and renal impairment alters the clearance and balance of magnesium. Significant supplemental magnesium in a patient with vancomycin-associated acute kidney injury can accumulate and cause hypermagnesemia. There is no direct chemical interaction, but renal monitoring is warranted.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Emerging evidence

Intravenous vancomycin is nephrotoxic, particularly at high troughs or with prolonged courses, and renal impairment alters the clearance and balance of magnesium. Significant supplemental magnesium in a patient with vancomycin-associated acute kidney injury can accumulate and cause hypermagnesemia. There is no direct chemical interaction, but renal monitoring is warranted.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Magnesium Glycinate and Vancomycin

Pair type

Caution

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

CautionEmerging evidence

What is happening. Intravenous vancomycin is nephrotoxic, particularly at high troughs or with prolonged courses, and renal impairment alters the clearance and balance of magnesium. Significant supplemental magnesium in a patient with vancomycin-associated acute kidney injury can accumulate and cause hypermagnesemia. There is no direct chemical interaction, but renal monitoring is warranted.

Mechanism. Vancomycin-induced nephrotoxicity reduces glomerular filtration, impairing renal excretion of magnesium; exogenous magnesium can then accumulate, risking hypermagnesemia. The interaction is mediated by drug-induced renal impairment rather than direct binding.

Recommendation. Patients on IV vancomycin, especially prolonged or high-dose courses, should have renal function and serum magnesium monitored. Avoid high-dose magnesium supplementation in the setting of reduced kidney function unless directed by a clinician. Oral vancomycin (minimal systemic absorption) does not meaningfully interact with magnesium.

Stack Score

How it moves the number.

Effect on the composite score

If both Magnesium Glycinate and Vancomycin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Filippone EJ, et al. The Nephrotoxicity of Vancomycin. Clinical Pharmacology and Therapeutics. 2017.Needs sourceNo link
2Rybak MJ, et al. Therapeutic monitoring of vancomycin: a revised consensus guideline. American Journal of Health-System Pharmacy. 2020.Needs sourceNo link

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