Interaction databaseSupplement × SupplementReviewed May 2026

Magnesium Taurate and Melatonin, a synergy.

Melatonin and magnesium are commonly used in sleep routines, but direct stack evidence and optimal dosing vary.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

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From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
Magnesium Taurate and Melatonin
Pair type
Synergy
Evidence (highest tier)
Moderate
Source citations
1 source
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Synergy · Moderate evidence

Synergy

What is happening. Melatonin and magnesium are commonly used in sleep routines, but direct stack evidence and optimal dosing vary.

Mechanism. Magnesium participates in neuromuscular and sleep-related physiology; melatonin supports circadian timing. The combination should be presented as routine support, not a sleep-disorder treatment.

Recommendation. If combining melatonin with magnesium taurate, keep magnesium within 200-350 mg/day supplemental elemental magnesium unless clinician-supervised and keep melatonin use situational or clinician-guided for persistent insomnia.

Sources (1)
  1. Abbasi B et al. The effect of magnesium supplementation on primary insomnia in elderly. J Res Med Sci. 2012

Stack Score

How this pair moves the number.

Effect on the composite score

If both Magnesium Taurate and Melatonin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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