NutriStack
Ciprofloxacin and Magnesium Taurate, timing-sensitive.
Magnesium taurate dissociates in the gut to release free Mg2+, which chelates ciprofloxacin and dramatically reduces its absorption. Even modest doses of supplemental magnesium can lower fluoroquinolone bioavailability enough to cause treatment failure.
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At a glance
- Substances
- Ciprofloxacin and Magnesium Taurate
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Strong evidence
Timing Sensitive
What is happening. Magnesium taurate dissociates in the gut to release free Mg2+, which chelates ciprofloxacin and dramatically reduces its absorption. Even modest doses of supplemental magnesium can lower fluoroquinolone bioavailability enough to cause treatment failure.
Mechanism. Mg2+ from magnesium taurate chelates the 3-carboxyl and 4-oxo groups on the fluoroquinolone core, forming insoluble complexes that block intestinal absorption.
Recommendation. Take ciprofloxacin at least 2 hours before or 6 hours after magnesium taurate. Do not co-administer.
Minimum separation. 360
Sources (2)
- Eljaaly K, Helal A, Almandeel T, Algarni R, Alshehri S. Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study. Saudi J Biol Sci. 2021;28(12):6929-6932. PMID 34866992
- Wiesner A, Zagrodzki P, Gawalska A, Paśko P. Together or Apart? Revealing the Impact of Dietary Interventions on Bioavailability of Quinolones: A Systematic Review with Meta-analyses. Clin Pharmacokinet. 2024;63(6):773-818. PMID 38807006
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ciprofloxacin and Magnesium Taurate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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