Supplement × Supplement·a synergy·Emerging evidence
Both can promote sleepiness and may cause next-day grogginess.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Both can promote sleepiness and may cause next-day grogginess.
Mechanism. Additive CNS-calming and sleep-promoting effects.
Recommendation. Use low evening doses and avoid driving if morning sedation occurs.
Effect on the composite score
If both Magnolia Bark and Melatonin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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