NutriStack
Nattokinase and Royal Jelly, a caution.
Both supplements independently lower the body's clotting capacity, Royal Jelly by potentiating anticoagulation (as shown in a warfarin case report) and Nattokinase through documented fibrinolytic and antiplatelet activity. Used together they can compound this effect, increasing the theoretical risk of easy bruising, prolonged bleeding, or more pronounced anticoagulation, especially in anyone also taking a blood thinner, aspirin, fish oil, or other antiplatelet supplement.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Nattokinase and Royal Jelly
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 3 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both supplements independently lower the body's clotting capacity, Royal Jelly by potentiating anticoagulation (as shown in a warfarin case report) and Nattokinase through documented fibrinolytic and antiplatelet activity. Used together they can compound this effect, increasing the theoretical risk of easy bruising, prolonged bleeding, or more pronounced anticoagulation, especially in anyone also taking a blood thinner, aspirin, fish oil, or other antiplatelet supplement.
Mechanism. Additive effect on hemostasis. Royal Jelly has a documented ability to potentiate anticoagulation: a published case report describes an elevated INR (rising to roughly 7.29) with hematuria in a warfarin-treated patient after starting Royal Jelly, indicating it can meaningfully shift coagulation. Nattokinase independently reduces clotting through fibrinolytic activity (direct fibrin degradation, enhanced plasmin generation) plus an antiplatelet action (reduced platelet aggregation and thromboxane formation). Taken together, the two act on overlapping limbs of the clotting cascade, producing an additive reduction in clot formation and stability.
Recommendation. Most healthy adults not on blood thinners can use both, but watch for easy bruising, nosebleeds, bleeding gums, or prolonged bleeding from cuts. Do NOT combine without medical supervision if you take warfarin, a DOAC, aspirin, clopidogrel, or other antiplatelet/anticoagulant agents. Stop both at least 1 to 2 weeks before any surgery or dental extraction. If you choose to use both, keep Nattokinase at conservative doses (around 2,000 FU per day) and report any unusual bleeding to your clinician.
Minimum separation. Timing separation does not mitigate this systemic additive effect; total daily exposure is what matters, not spacing.
Sources (3)
- Lee NJ et al. Warfarin and royal jelly interaction. Pharmacotherapy. 2006;26(4):583-6. PMID 16553520
- Weng Y et al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017;18(3). PMID 28264497
- Kurosawa Y et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601. PMID 26109079
Stack Score
How this pair moves the number.
Effect on the composite score
If both Nattokinase and Royal Jelly are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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