NutriStack
NMN and PQQ, a synergy.
PQQ and NMN act on convergent mitochondrial and NAD-related pathways, supporting mitochondrial biogenesis and cellular energy metabolism through complementary routes.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. PQQ and NMN act on convergent mitochondrial and NAD-related pathways, supporting mitochondrial biogenesis and cellular energy metabolism through complementary routes.
Mechanism. NMN raises intracellular NAD+ to fuel sirtuin activity, and sirtuin signaling converges with PQQ-induced PGC-1-alpha activation to promote mitochondrial biogenesis.
Recommendation. Reasonable to take together for energy and mitochondrial support. No timing separation required.
Sources (2)
- Chowanadisai W et al. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1-alpha expression. Journal of Biological Chemistry, 2010
- Yoshino J et al. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metabolism, 2018
Stack Score
How this pair moves the number.
Effect on the composite score
If both NMN and PQQ are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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