What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the NMN + Urolithin A pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Insufficient evidence

NMN + Urolithin A

Q: Can I take NMN and Urolithin A together?

Yes. The combination of NMN and Urolithin A produces a measurable benefit. Both target mitochondrial and cellular-energy pathways through complementary mechanisms: Urolithin A clears damaged mitochondria via mitophagy while NMN supports NAD+ levels that fuel mitochondrial metabolism.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Insufficient evidence

Both target mitochondrial and cellular-energy pathways through complementary mechanisms: Urolithin A clears damaged mitochondria via mitophagy while NMN supports NAD+ levels that fuel mitochondrial metabolism.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

NMN and Urolithin A

Pair type

Synergy

Evidence

Insufficient

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyInsufficient evidence

What is happening. Both target mitochondrial and cellular-energy pathways through complementary mechanisms: Urolithin A clears damaged mitochondria via mitophagy while NMN supports NAD+ levels that fuel mitochondrial metabolism.

Mechanism. Urolithin A promotes mitophagy and biogenesis; NMN raises NAD+ availability supporting mitochondrial enzymatic function. Theoretically complementary.

Recommendation. May be combined by those pursuing mitochondrial and longevity goals. No specific timing requirement. Human data on the combination are limited.

Stack Score

How it moves the number.

Effect on the composite score

If both NMN and Urolithin A are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Andreux PA et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults. Nature Metabolism. 2019.Needs sourceNo link

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