What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Resveratrol + Urolithin A pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Insufficient evidence

Resveratrol + Urolithin A

Q: Can I take Resveratrol and Urolithin A together?

Yes. The combination of Resveratrol and Urolithin A produces a measurable benefit. Both are studied within the polyphenol/longevity space and influence mitochondrial biogenesis pathways, though by different mechanisms.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Insufficient evidence

Both are studied within the polyphenol/longevity space and influence mitochondrial biogenesis pathways, though by different mechanisms.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Resveratrol and Urolithin A

Pair type

Synergy

Evidence

Insufficient

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyInsufficient evidence

What is happening. Both are studied within the polyphenol/longevity space and influence mitochondrial biogenesis pathways, though by different mechanisms.

Mechanism. Urolithin A induces mitophagy; resveratrol is reported to activate sirtuin/PGC-1-alpha-related signaling supporting mitochondrial biogenesis. Overlap is mechanistic and theoretical.

Recommendation. May be combined for general longevity goals; no known adverse interaction. Take with food.

Stack Score

How it moves the number.

Effect on the composite score

If both Resveratrol and Urolithin A are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Andreux PA et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults. Nature Metabolism. 2019.Needs sourceNo link

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One pair was the worked example.

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Open the interaction checker → Browse the research index