NutriStack
Omeprazole and Zinc Carnosine, a synergy.
Zinc-L-carnosine (polaprezinc) is a mucosal-protective chelate widely used in Japan for gastritis and ulcer healing. It is well studied as an adjunct to acid suppression and to H. pylori eradication therapy, with evidence for faster ulcer healing and improved gastric mucosal repair. It complements rather than competes with omeprazole.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Omeprazole and Zinc Carnosine
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Zinc-L-carnosine (polaprezinc) is a mucosal-protective chelate widely used in Japan for gastritis and ulcer healing. It is well studied as an adjunct to acid suppression and to H. pylori eradication therapy, with evidence for faster ulcer healing and improved gastric mucosal repair. It complements rather than competes with omeprazole.
Mechanism. Zinc-L-carnosine adheres to ulcer beds, scavenges reactive oxygen species, stabilizes mast cells, and promotes mucosal epithelial repair. These effects are mechanistically additive to omeprazole's acid suppression.
Recommendation. If you have gastritis, an ulcer, or NSAID-related GI symptoms on omeprazole, ask your prescriber about adding zinc-L-carnosine 75 mg twice daily. The combination is well tolerated for short courses (4-8 weeks).
Stack Score
How this pair moves the number.
Effect on the composite score
If both Omeprazole and Zinc Carnosine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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