NutriStack
Prednisolone and Vitamin D2, a synergy.
Prednisolone increases fracture risk when used chronically by accelerating bone loss. Vitamin D2 can help maintain vitamin D status, which supports calcium absorption and is part of standard glucocorticoid-induced osteoporosis prevention.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Prednisolone and Vitamin D2
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Prednisolone increases fracture risk when used chronically by accelerating bone loss. Vitamin D2 can help maintain vitamin D status, which supports calcium absorption and is part of standard glucocorticoid-induced osteoporosis prevention.
Mechanism. Glucocorticoids impair osteoblast function, increase bone resorption, and reduce calcium balance. Vitamin D2 supports intestinal calcium absorption by increasing circulating 25-OH vitamin D.
Recommendation. If prednisolone use is prolonged, maintain vitamin D status with diet, sunlight exposure where appropriate, or supplementation such as vitamin D2. Have bone risk assessed rather than assuming vitamin D2 alone is enough protection.
Sources (2)
- Humphrey MB, Russell L, Danila MI, et al. 2022 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. Arthritis Care Res (Hoboken). 2023;75(12):2405-2419. PMID 37884467
- Homik J, Suarez-Almazor ME, Shea B, Cranney A, Wells G, Tugwell P. Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst Rev. 2000;1998(2):CD000952. PMID 10796394
Stack Score
How this pair moves the number.
Effect on the composite score
If both Prednisolone and Vitamin D2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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